NEW STEP BY STEP MAP FOR PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to some conserved spouse and children of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to diverse stimuli12, triggering the buil